Acetylhexapeptide-8, also known as acetylhexapeptide-3. Acetylhexapeptide-8 is a kind of high-quality anti wrinkle raw material, which has high anti wrinkle activity and small side effects, and has been used in many high-end cosmetics. Acetylhexapeptide-8 can locally block the nerve transmission of muscle contraction information, affect the nerve conduction of the skin capsule, relax the facial muscles, and smooth the dynamic, static and fine lines; it can effectively reorganize the collagen elasticity, increase the activity of elastin, relax the facial lines, smooth and improve the relaxation of wrinkles.
Acetylhexapeptide-8 has a similar effect to botu-linum to-xin. Because of a series of side effects of botu-linum to-xin, including pain caused by puncture, erythema, edema and blepharoptosis caused by toxin diffusion, facial asymmetry and difficulty in speaking, it is urgent to find new substitutes, and Acetylhexapeptide-8 emerges from a series of compounds. Its efficacy is comparable to that of botu-linum to-xin A, but it avoids the disadvantage of botu-linum to-xin that must be injected and used at high cost.
Mechanism of Acetylhexapeptide-8:
Muscle contraction occurs when receiving neurotransmitters. Neurotransmitters are synthesized in the cell body of neurons and stored in synaptic vesicles. When stimulated by the outside world, a kind of extracellular secretion (called SNARE protein combination) that is calcium dependent causes synaptic vesicles to release neurotransmitters, which reach the postsynaptic membrane through synaptic gap and interact with corresponding receptors. Snare is composed of three proteins: vamp, syntaxin and SNAP-25.
The structure of Acetylhexapeptide-8 is similar to SNAP-25, which competes with SNAP-25 to occupy the position of SNAP-25 in the SNARE complex, thus inhibiting the formation of snare, making muscles unable to effectively receive neurotransmitters, limiting muscle contraction, and finally preventing skin wrinkles. In addition, excessive release of catecholamine can also cause wrinkles. Acetylhexapeptide-8 can inhibit the release of catecholamine. Acetylhexapeptide-8 is a kind of botu-linum to-xin mechanism. By inhibiting the synthesis of SNARE receptor, inhibiting the excessive release of catecholamine and acetylcholine in the skin, locally blocking the nerve transmission of muscle contraction information, affecting the nerve conduction of the skin capsule, relaxing the facial muscles, and achieving the purpose of smoothing the dynamic, static and fine lines. However, it is different from the anesthesia mechanism of botu-linum to-xin A, allowing muscles to move and express naturally, so it has no other side effects.
Acetylhexapeptide-8 can be used in various anti-aging personal care products
1, Eye care: it can remove wrinkles and crow's feet.
2, Facial care: it can obviously remove the wrinkles of forehead caused by muscle contraction.