L-carnosine is a dipeptide composed of β - alanine and L-histidine, which is a crystalline solid. Muscle and brain tissues contain high concentrations of L-carnosine. L-carnosine was discovered by Russian chemist gulevich along with carnitine. Studies in the United Kingdom, South Korea, Russia and other countries have shown that L-carnosine has strong antioxidant capacity and is beneficial to human body. L-carnosine has been proved to be able to scavenge reactive oxygen species (ROS) and α - β unsaturated aldehydes formed by excessive oxidation of fatty acids in cell membrane during oxidative stress.
Many studies have found that L-carnosine has a good effect on the prevention and treatment of cataract, One of the studies has shown that L-carnosine can improve the cataract caused by lens opacification caused by guan-idine exposure. Although these claims support the treatment of cataract and other hypothetical benefits of L-carnosine on the eyes, so far, it has not been fully supported by the mainstream medical community, It is suggested that L-carnosine is neither safe nor effective in local treatment of cataract.
In a 2002 study report, L-carnosine can improve the relationship between autistic children and society and increase the vocabulary used by autistic children. However, the improvement claimed in the study may also come from maturity, placebo effect or other factors not included in the study.
In animal experiments, L-carnosine supplementation can increase cortisol content, which may explain the hyperactivity symptoms caused by high-dose L-carnosine. However, the above-mentioned study was that L-carnosine was injected into chicken ventricles, and the phenomenon of increased cortisol content has not been seen in human experiments. In animal experiments, L-carnosine has been found to delay the growth of cancer cells, prevent oxidative stress caused by alcohol and chronic liver injury caused by alcohol. In mouse experiments, L-carnosine's neuroprotective mechanism can prevent permanent cerebral ischemia.
L-carnosine can enhance the hefrek limit of human fibroblasts and the rate of telomere shortening. The maintenance of telomere may benefit the growth of some potential cancers, so L-carnosine is also considered as a protective agent.
It is generally believed that typical vegetarians lack the intake of L-carnosine, but it is still unknown whether this will cause adverse effects.
Application scope of L-carnosine
1. L-carnosine is a new food additive.
2. L-carnosine is a dipeptide composed of β - alanine and histidine, which can be synthesized in animals.
3. L-carnosine can significantly inhibit lipid oxidation induced by free radicals and metal ions. In meat processing, L-carnosine can inhibit lipid oxidation and protect meat color. L-carnosine and phytic acid can resist beef oxidation. 9 g / kg L-carnosine could improve meat color and oxidative stability of skeletal muscle, and had synergistic effect with vitamin E.
4. In cosmetics, L-carnosine has the effect of preventing skin aging and whitening. L-carnosine can prevent the occurrence of free radicals caused by smoking, which are more harmful to the skin than sunlight. Free radicals are highly active atoms or atomic groups in human body, which can oxidize other substances in human body.
5. L-carnosine has antioxidant properties and is a natural antioxidant.
6. L-carnosine can enhance the transmittance of turbid human eye crystals. The use of L-carnosine as the raw material of antioxidant preparation can treat senile cataract.
Oral administration of carnose-7 can promote wound healing, especially in surgery.